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Cadmium Toxicity Induces Pyroptosis In Macrophages

Samuel Camilli, Carli Busler,Apoorva Desaraju,Ramani Soundararajan,Richard Lockey

Journal of Allergy and Clinical Immunology（2023）

Cited 0|Views6
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Abstract
Cadmium (Cd) toxicity contributes to chronic obstructive pulmonary disease (COPD) and other smoking-related lung disease. Caspase-1, gasdermin D (GSDMD), and gasdermin E (GSDME) are key proteins responsible for the initiation of pyroptosis. We hypothesize Cd induces host immune and inflammatory cell death in a macrophage model (RAW 264.7).
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macrophages
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