Investigation of Tryptase Gene Composition as a Potential Biomarker of Food Allergy Reaction Severity

Abigail Lang,Stephanie Kubala, Pamela Guerrerio,Jacqueline Pongracic,Rajesh Kumar,Jonathan Lyons

Journal of Allergy and Clinical Immunology（2023）

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摘要

Increased TPSAB1 copy number encoding ⍺-tryptase is associated with severe reactions in adults with Hymenoptera venom allergy, systemic mastocytosis, and idiopathic anaphylaxis. Tryptase gene composition as a potential biomarker for food allergy severity has not been studied. We hypothesized that increased relative TPSAB1 copy number encoding ⍺-tryptase would be enriched in children with severe reactions to peanut.

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关键词

tryptase gene composition,food allergy reaction severity,food allergy,potential biomarker

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