Severe Sarcoidosis Exhibits Loss of Immunological Regulation In MAPK, WNT, and PI3K Pathways

Kai Huang,Yue Huang,Christen Vagts,Christian Ascoli,Nadera Sweiss,David Perkins,Patricia Finn

Journal of Allergy and Clinical Immunology（2023）

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摘要

Sarcoidosis is a complex immunological disorder with varied progression. Disease course can vary greatly between mild and severe cases, with severe cases leading to systemic spread and organ damage. We hypothesized that the transcriptomic regulation of immune function differentiates severe and mild cases.

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severe sarcoidosis exhibits loss,immunological regulation

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