Strategy for neonatal discrimination between Filaggrin-wildtype neonates and Fillagrin loss of function mutation carriers for the purpose of preventative AD-treatment

Gerwin Puppels,Claudio Nico,Dhanis Lad,Carol Ni Chaoimh,Peter Caspers,John Common,Alan Irvine

Journal of Allergy and Clinical Immunology（2023）

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Abstract

Loss-of-function filaggrin (LoF-FLG)-mutation carriers are at higher risk of early, more severe Atopic Dermatitis (AD) than wild type (WT-FLG) infants . We present a strategy for early discrimination between WT-FLG and LoF-FLG-mutation carriers, based on Raman spectroscopic analysis of Natural Moisturizer Factor (NMF) content in the stratum corneum of the thenar eminence.

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Key words

neonatal discrimination,function mutation carriers,fillagrin loss,filaggrin-wildtype,ad-treatment

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