Chemogenetics for Gene Therapy Based Targeted Cardiac Electrophysiological Modulation.

HomeCirculation ResearchVol. 132, No. 5Chemogenetics for Gene Therapy Based Targeted Cardiac Electrophysiological Modulation No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextChemogenetics for Gene Therapy Based Targeted Cardiac Electrophysiological Modulation Yehuda Wexler, Matteo Ghiringhelli, Naim Shaheen, Shany Glatstein, Irit Huber, Oded Edri, Yousef Abboud, Michal Landesberg, Daniel Shiff, Gil Arbel and Lior Gepstein Yehuda WexlerYehuda Wexler https://orcid.org/0000-0002-9586-9109 Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Search for more papers by this author , Matteo GhiringhelliMatteo Ghiringhelli Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Search for more papers by this author , Naim ShaheenNaim Shaheen Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Search for more papers by this author , Shany GlatsteinShany Glatstein Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Search for more papers by this author , Irit HuberIrit Huber Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Search for more papers by this author , Oded EdriOded Edri Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Search for more papers by this author , Yousef AbboudYousef Abboud Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Search for more papers by this author , Michal LandesbergMichal Landesberg Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Search for more papers by this author , Daniel ShiffDaniel Shiff Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Search for more papers by this author , Gil ArbelGil Arbel Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Search for more papers by this author and Lior GepsteinLior Gepstein Correspondence to: Lior Gepstein, MD, PhD, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, PO 9649, Haifa, 3109601, Israel. Email E-mail Address: [email protected] https://orcid.org/0000-0002-5351-7391 Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, the Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, Haifa, Israel (Y.W., M.G., N.S., S.G., I.H., O.E., Y.A., M.L., D.S., G.A., L.G.). Cardiology Department, Rambam Health Care Campus, Haifa, Israel (L.G.). Search for more papers by this author Originally published6 Feb 2023https://doi.org/10.1161/CIRCRESAHA.122.322041Circulation Research. 2023;132:645–647is related toMeet the First AuthorsFootnotesFor Sources of Funding and Disclosures, see page 647.Correspondence to: Lior Gepstein, MD, PhD, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, PO 9649, Haifa, 3109601, Israel. Email [email protected]ac.ilReferences1. Lei M, Wu L, Terrar DA, Huang CLH. Modernized classification of cardiac antiarrhythmic drugs.Circulation. 2018; 138:1879–1896. doi: 10.1161/circulationaha.118.035455LinkGoogle Scholar2. Liu YW, Chen B, Yang X, Fugate JA, Kalucki FA, Futakuchi-Tsuchida A, Couture L, Vogel KW, Astley CA, Baldessari A, et al. Human embryonic stem cell-derived cardiomyocytes restore function in infarcted hearts of non-human primates.Nat Biotechnol. 2018; 36:597–605. doi: 10.1038/nbt.4162CrossrefMedlineGoogle Scholar3. Magnus CJ, Lee PH, Bonaventura J, Zemla R, Gomez JL, Ramirez MH, Hu X, Galvan A, Basu J, Michaelides M, et al. Ultrapotent chemogenetics for research and potential clinical applications.Science. 2019; 364:eaav5282. doi: 10.1126/science.aav5282CrossrefMedlineGoogle Scholar4. Shaheen N, Shiti A, Huber I, Shinnawi R, Arbel G, Gepstein A, Setter N, Goldfracht I, Gruber A, Chorna SV, et al. Human induced pluripotent stem cell-derived cardiac cell sheets expressing genetically encoded voltage indicator for pharmacological and arrhythmia studies.Stem Cell Rep. 2018; 10:1879–1894. doi: 10.1016/j.stemcr.2018.04.006CrossrefMedlineGoogle Scholar5. Donahue JK. Current state of the art for cardiac arrhythmia gene therapy.Pharmacol Ther. 2017; 176:60–65. doi: 10.1016/j.pharmthera.2017.06.005CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesMeet the First AuthorsCirculation Research. 2023;132:542-544 March 3, 2023Vol 132, Issue 5 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.122.322041PMID: 36744466 Manuscript receivedSeptember 25, 2022Manuscript acceptedJanuary 19, 2023Originally publishedFebruary 6, 2023Manuscript revisedJanuary 17, 2023 Keywordscardiomyocytesreceptors, serotoninbiological pacemakersgene therapy, arrhythmiavareniclinehuman-induced pluripotent stem cellsPDF download Advertisement SubjectsCell TherapyElectrophysiologyGene TherapyIon Channels/Membrane TransportStem Cells