Development of cottonseed-based emulsions for encapsulation of vitamin A

Nanoemulsions are nanoscale self-assembled entities which are manufactured for improving the delivery of active pharmaceutical ingredients. Nanoemulsion technology is one of the best ways to encapsulate the functional components as it enhances the stability and bioavailability of the compound. In the present study, nanoemulsions were prepared by ultrasonic homogenization of dispersed phase (10-22%) and surfactants (3-9%) with vitamin A (0.25-2.5%). Nanoemulsions were characterized through various optical techniques and stability was assessed using thermal shock and freeze-thaw cycle. The results revealed that nanoemulsions with high percentage of surfactants were more stable and retained smaller particle size as compared to nanoemulsions with low surfactants percentage and high dispersed phase, contributed to phase separation and colour change. These emulsions can be further tested for any toxic/allergic effect on the biological model and may be incorporated into food products.