Dinitrosyl iron complexes protect hemoglobin from oxidation
Conference Proccedings NT+ME'22(2022)
Abstract
Hemoglobin-bound dinitrosyl iron complexes (Hb-DNICs) are dose-dependently degraded by peroxynitrite. At the same time, they protect Hb from oxidative modification: they prevent the formation of carbonyl derivatives, the oxidation of tryptophan residues, the degradation of the heme group, and the formation of crosslinks between subunits.
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