Dinitrosyl iron complexes protect hemoglobin from oxidation

Hemoglobin-bound dinitrosyl iron complexes (Hb-DNICs) are dose-dependently degraded by peroxynitrite. At the same time, they protect Hb from oxidative modification: they prevent the formation of carbonyl derivatives, the oxidation of tryptophan residues, the degradation of the heme group, and the formation of crosslinks between subunits.