Metformin as a Potential Antitumor Agent
Serbian Journal of Experimental and Clinical Research(2022)
Abstract
Abstract Some recent findings suggest that metformin, an oral antidiabetic drug, may have antitumor properties. Studies have shown that metformin can alter cell metabolism, both tumor and immune cells, which can greatly influence disease outcome. In this review, we discuss the potential mechanisms in which metformin can directly induce apoptosis of tumor cells as well as mechanisms in which metformin can elicit or enhance antitumor immune response.
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Key words
metformin,potential antitumor agent
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