Correction: AMP-activated protein kinase α1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation
Journal of Biological Chemistry(2023)
摘要
AMP-activated protein kinase α1 promotes atherogenesis by increasing monocyte-to-macrophage differentiationJournal of Biological ChemistryVol. 292Issue 19PreviewMonocyte-to-macrophage differentiation, which can be initiated by physiological or atherogenic factors, is a pivotal process in atherogenesis, a disorder in which monocytes adhere to endothelial cells and subsequently migrate into the subendothelial spaces, where they differentiate into macrophages and macrophage-derived foam cells and cause atherosclerotic lesions. However, the monocyte-differentiation signaling pathways that are activated by atherogenic factors are poorly defined. Here we report that the AMP-activated protein kinase α1 (AMPKα1) in monocytes promotes atherosclerosis by increasing monocyte differentiation and survival. Full-Text PDF Open Access In the legends for Figure 2F and Figure 4E the authors inadvertently omitted to declare that Figure 2F and Figure 4E include the same β-actin image. The authors state that the same β-actin image served as loading control for both western blots since the blots were done in the same sets of gels with different antibodies on the same day. Also, the concentration of M-CSF 20 ng/mL in Figure 4E legend was incorrect. The correct concentration of M-CSF was 40 ng/mL. The authors state that the scientific conclusions of the article are not affected by the correction.
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关键词
protein kinase α1,atherogenesis,protein kinase,amp-activated,monocyte-to-macrophage
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