Synthesis of Chiral 1,4,2-Oxazaphosphorinanes Bearing Pyridyl Substituents
Russian Journal of General Chemistry(2023)
摘要
A series of 1,4,2-oxazaphosphorinanes was synthesized by the three-component reaction of chiral pyridylcontaining imines with trialkyl phosphites and monochloroacetic acid, followed by dealkylation of the P(O)OAlk-fragments of intermediates. It was established that the major diastereomers of the obtained heterocycles have the same configuration at both chiral centers. The synthesized 1,4,2-oxazaphosphorinanes show catalytic activity in the Friedel–Crafts reaction.
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关键词
1,4,2-oxazaphosphorinanes,chiral 1,2-amino alcohols,imines,phosphonylation,aminophosphonic acids
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