Suicide attempts in adolescents with cystic fibrosis on Elexacaftor/Tezacaftor/Ivacaftor therapy

Meliksah Arslan,Sarah Chalmers,Kelly Rentfrow,Janelle M. Olson,Vicki Dean,Mark E. Wylam,Nadir Demirel

Journal of Cystic Fibrosis（2023）

Cited 8|Views13

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Abstract

•We report 2 adolescents with CF who attempted suicide shortly after starting ETI.•Mental adverse effects of CFTR modulators were reported in previous studies.•Impact of chronic disease and the COVID-19 pandemic are likely contributing factors.•Providers should be vigilant of mental health issues in adolescent with CF on ETI.•Mental health screening should be performed regularly after initiation of ETI therapy.

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Key words

Cystic fibrosis,Elexacaftor/tezacaftor/ivacaftor,Suicide,Depression,Adolescent,Mental health,Covid-19 pandemic,Mental adverse effects

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