Characteristics of Retinal Image in Women with Recurrent Spontaneous Abortion

Abstract Purpose To identify the characteristics of retinal image in women with recurrent spontaneous abortion (RSA). Methods A case-control study was conducted in the Shenzhen Maternity & Child Healthcare Hospital. Eighty women who were diagnosed RSA were recruited. Those women who were age matched with the RSA group and experienced a successful birth history were chosen as the control group. Retinal images were collected and characteristics were analysed. Multivariable logistic model was built to identify the characteristics of retinal image. Results Compared to the control group, the patients with RSA had higher CRAE (P = 0.02), Vasym(P < 0.0001) and Aasym(P = 0.002), larger Aangle(P = 0.035), BCA(P < 0.0001) and more obvious Nicking(P = 0.001) and occlusion( P = 0.001) in the retinal artery, but lower AVR(P = 0.314) in retinal characteristics. The area under the ROC curve of the multivariable logistic regression was 0.8541 (95% C.I. 0.796–0.912). Conclusions Compared to the Normal pregnancy women, those with RSA had special retinal characteristics, which might provide useful information for RSA identification.