Efficacy and safety of medical treatment in the clinical management of adolescents with gender dysphoria (gd): a prospective follow-up study

Objectives The present study assessed the efficacy of Gonadotropin-Releasing Hormone agonists (GnRHas) treament and Gender Affirming Hormonal Treatment (GAHT) in terms of psychological functioning and physical changes in a sample of adolescents with GD assessed at the Florence Gender Incongruence Unit. Methods Thirty adolescents -17 assigned Female at birth (AFAB) and 13 assigned male at birth (AMAB)- were evaluated at first referral (T0), shortly before the start of GnRHa (Triptorelin; T1) and after an average follow-up of 7 ±3.18 months (T2). Moreover, a subgroup of seventeen adolescents (11 AFAB and 6 AMAB) was evaluated after six months (T3) of GAHT. At each time point physical and biochemical examinations were performed, and general phsychopatology, depressive symptoms and suicidal risk were measured through validated questionnaires (Youth Self Report (YSR), Beck Depression Inventory (BDI); Multi-Attitude Suicide Tendency Scale (MAST)). Results Average age of adolescents at T1 was 14.4± [if gte msEquation 12]>± ± 更多