Design, synthesis of 10-alkoxy-5-spiro CPT and preliminary biological evaluation in vitro

A series of 10-alkoxy-5-spirocycle campthothecin derivatives were synthesized in a convenient method. On the one hand, the solubility of these compounds was obviously modified; on the other hand, most of these 5-spirocycle campthothecin derivatives showed a better inhibition activity against MGC803 cell line.