Investigating neuroinflammation in lateral fluid percussion injury

Neuroinflammation is a major culprit of many long-term consequences of traumatic brain injury (TBI). Lateral fluid percussion injury (lFPI) is a well-established model with focal and diffuse characteristics of injury including ipsilateral and contralateral effects. First adapted for rodent models in 1987, lFPI has since become one of the most characterized experimental brain injury models. From intracellular dysregulation to behavioral deficits, work in lFPI-induced neuroinflammation has elucidated many mechanisms of injury that provide promising targets for long-term treatment of post-injury consequences. Here, we provide a brief overview of lFPI as a robust, neuroinflammatory model with high translatable potential.