Safety and Effectiveness of Maternal COVID-19 Vaccines Among Pregnant People and Infants

In conclusion, pregnant people are at increased risk of severe disease and adverse pregnancy outcomes from COVID-19, but initial COVID-19 vaccine clinical trials excluded pregnant people. Postauthorization studies have been important to fill evi-dence gaps regarding COVID-19 vaccine safety and effectiveness in pregnant people and infants, and lessons learned from the COVID-19 pandemic include the importance of including pregnant people in clinical trials when possible. Evidence has consistently demonstrated that COVID-19 mRNA vaccines are safe when given during pregnancy for both pregnant people and infants, and COVID-19 mRNA vaccines protect pregnant people and their infants who are too young to receive COVID-19 vaccines. Monovalent vaccine effectiveness was lower during Omicron predominance, and bivalent vac-cines may improve protection against Omicron variants. Everyone, including people who are pregnant, breastfeeding, trying to get pregnant now, or might become preg-nant in the future, should stay up to date with recommended COVID-19 vaccines and get the recommended bivalent booster, when eligible.