PD.02.02 Lung TS: A New 6-Gene Signature for Prediction of Response to Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer Patients

Pedro De Marchi,Letícia Ferro Leal,Luciane Sussuchi da Silva,Eduardo Caetano Albino Silva,Augusto Obuti Saito,Vladmir C. Cordeiro de Lima,Cristina Aguado,Maria González-Cao, Miguel Angel Molina-Vila,Rui Manuel Reis

Journal of Thoracic Oncology（2023）

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摘要

Immune checkpoint inhibitors (ICIs) are associated with durable antitumor activity in advanced non-small cell lung cancer (NSCLC), however, selection of the best candidates for this type of therapy is a challenge. PD-L1 expression is the predictive biomarker of response to ICIs, but it is not completely discriminatory between responders and non-responders. Gene expression profile (GEP) is a promising tool to fill this gap.

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关键词

immune checkpoint inhibitors,cell lung cancer,lung cancer,non-small

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