Stress Hyperglycemia Drives the Risk of Hospitalization for Chest Pain in Patients with Ischemia and Non-Obstructive Coronary Arteries (INOCA)

OBJECTIVE

Ischemia with non-obstructive coronary arteries (INOCA) is a prevailing finding in patients with angina. However, the main factors underlying the risk of being re-hospitalized for chest pain in patients with INOCA remain mostly unknown.

RESEARCH DESIGN AND METHODS

We evaluated INOCA patients referred to the “Casa di Cura Montevergine”, Mercogliano (Avellino), Italy, since January 2016 to January 2021 for percutaneous coronary intervention (PCI). In these subjects, we assessed the impact of stress hyperglycemia ratio (SHR) on the risk of re-hospitalizations for chest pain.

RESULTS

2874 patients with INOCA successfully completed the study. At 1-year follow-up, the risk of re-hospitalization for chest pain was significantly higher (p<0.001) in INOCA patients with SHR>1, compared to patients with SHR≤1.

These findings were confirmed by multivariable analyses (adjusting for potential confounders including age, body mass index, blood pressure, heart rate, chronic kidney disease, and cholesterol), propensity score matching, and inverse probability of treatment weighting.

CONCLUSIONS

Our data indicate that SHR on hospital admission significantly increases the risk of re-hospitalizations for chest pain in INOCA patients.