A loop-mediated isothermal amplification (lamp)-based point-of-care system for rapid on-site clinical detection of sars-cov-2 viruses

Trieu Nguyen,Aaydha Chidambara Vinayaka,Van Ngoc Huynh,Quyen Than Linh,Sune Zoega Andreasen,Mohsen Golabi,Dang Duong Bang,Jens Kjolseth Moller,Anders Wolff

2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS)（2023）

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Abstract

In the ongoing COVID-19 pandemic, sensitive and rapid on-site detection of the SARS-CoV-2 coronavirus has been one of crucial objectives. A point-of-care (PoC) device called PATHPOD for quick, on-site detection of SARS-CoV-2 employing a real-time reverse-transcription loop-mediated isothermal amplification (RT-rLAMP) reaction on a polymer cartridge. The PATHPOD consists of a standalone device (weighing under 1.2 kg) and a cartridge, and can identify 10 distinct samples and 2 controls in less than 50 minutes. The PATHPOD PoC system is fabricated and clinically validated for the first time in this work

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Key words

SARS-CoV-2,point-of-care,COVID-19,LAMP,limit of detection,open-source hardware,total internal reflection,TIR

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