Bioengineering 3D Neural Networks Using Magnetic Manipulations (Adv. Funct. Mater. 50/2022)

Neural Engineering In article number 2204925, Orit Shefi and co-workers depict that neurons are transformed into magnetic units and dynamically localized within 3D biomaterials using magnetic manipulations. Iron-oxide nanoparticles are synthesized and incorporated into neurons, which are then subjected to various magnetic fields. The neurons' movement is controlled inside multi-layered 3D collagen scaffolds simulating in-vivo tissue structures, thus constructing pre-designed, viable and functional 3D microarchitectures of neural networks.