Influence of a highly porous ceramic implant based on zirconium oxide (zro2) on bone tissue regeneration

The purpose of this experimental work was to determine the regeneration ability of bone tissue due to modern bioceramics synthesized and obtained using the previously developed method of reactive spark plasma sintering (Spark Plasma Sintering-Reactive Synthesis, SPS-RS). The study was performed on 26 laboratory rabbits - females of the New Zealand White breed, divided into two groups. The evaluation of the regeneration of the burr hole after covering the defect with a bioceramic implant was performed by the method - (BMD) X-ray densitometry on days 7, 40, 210 after surgery. As a result of the study, there was a tight fixation of the implant in the area of ​​the bone tissue defect without its dislocation. There were no signs of osteoporosis and osteolysis in the surrounding bone tissues. And on the 210th day after the operation, according to densitometric data, the formation of dense bone tissue was observed. The use of a bioceramic implant makes it possible to immediately close large bone defects and to stimulate the formation of dense bone structures around them.