Click-based injectable bioactive PEG-hydrogels guide rapid craniomaxillofacial bone regeneration by the spatiotemporal delivery of rhBMP-2

Weiwei Lao,Lijie Fan,Qiao Zhang, Chaoqian Lou,Hang Li, Yanyan Li,Shuang Wu,Xiaojun Li,Qiaojie Luo,Weipu Zhu,Xiaodong Li

Journal of Materials Chemistry B（2023）

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摘要

A novel click-based bioactive injectable hydrogel based on two PEG derivatives realizes the efficient loading of rBMSCs and spatiotemporal delivery of rhBMP-2, basically accomplishing repair and regeneration of a critical-size defect within 4 weeks.

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