Experimental study of medical isotopes ^62,64Cu and ⁶⁸Ga production using intense picosecond laser pulse

Abstract Radioisotopes are indispensable agents in medical diagnosis and treatment, among which copper-62, 64 (62,64Cu) and gallium-68 (68Ga) are medical isotopes widely used in positron emission tomography (PET) imaging. Experiments that generate these radioisotopes via laser-induced photonuclear reactions were performed on the XingGuangIII laser facility of the Laser Fusion Research Center in Mianyang. High-charge ( Q e ∼ 40 nC) MeV electron (e− ) beams were generated with 100 terawatts, picosecond laser pulses. The e− beams were then impinged on a metal stack composed of Ta foil and activation plates (natural Cu and Ga2O3), producing high-energy bremsstrahlung x-rays and medical isotopes 62,64Cu and 68Ga, respectively. The characteristic emissions of the produced 62,64Cu and 68Ga were detected off-line , and the production yields of 62,64Cu and 68Ga were obtained to be of the order of 106 per laser shot. For electrons with energy higher than 8 MeV, the dependence of isotope production efficiency (per e− ) on electron temperature ( T e ) is investigated through Geant4 simulations. It is found that the production efficiency increases with the T e . At T e ∼ 10 MeV, the values are 10−4 for 62Cu and 2 × 10 − 5 for 68Ga, respectively. The prospect of producing the medical isotopes 62,64Cu and 68Ga are further evaluated using a table-top femtosecond laser system of high repetition. With a repetition rate of 100 Hz, their activity is expected to reach 0.2 GBq for 62Cu, 0.1 GBq for 64Cu and 0.05 GBq for 68Ga, respectively. Such activity would meet the required dose for clinical PET imaging, indicating the great potential to produce medical isotopes with an all-optical, high-repetition laser system.