Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice

•Orally administered polystyrene nanoparticles (PS-NPs) translocate into the circulatory system.•PS-NPs cause glycolipid and irreversible damage to organs in mice.•PS-NPs increase ROS levels and induce the inflammatory response.•Resveratrol mitigates insulin resistance and gluconeogenesis induced by PS-NPs in mice.