Evaluation of the antidiabetic and antioxidant effect of garlic juice on alloxan induce diabetic rat

Medicinal plants may provide valuable therapeutic agents in modern medicine and in traditional system, especially in areas where the modern drugs are unavailable, expensive or predispose to life threatening complications. One of these plants is Garlic (Allium L. liliaceae) which is used as foodstuff, condiment, and flavoring in folk medicine. The aim of this study was to investigate the effect of garlic juice on plasma glucose concentration and superoxide dismutase (SOD) activity on alloxan induced diabetic rats following injection with alloxan (120 mgkg-1 body weight) to diabetic treated and diabetic control group‘s intraperitoneally. Garlic juice (1ml/100g/body weight) was administered orally to diabetic treated once daily for 28 days. The result showed a statistically significant (P<0.05) decrease in plasma glucose concentration of diabetic treated at day 28 (112.86 ±2.10mg/dl) when compared to day 0 (202.09 ± 1.80mg/dl). SOD activity showed a statistical significant increase (P < 0.05) in the liver of diabetic treated when compared to in diabetic control. There was a statistical non-significant increase (P>0.05) in the heart and kidney of diabetic treated when compared to diabetic control. The result obtained in this study showed that garlic juice has antidiabetic and slight antioxidant effect in plasma and tissues (Liver, Heart andKidney