Predictors of an early and long-term improvement in ejection fraction after atrial fibrillation ablation among patients with cardiomyopathy

Atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) often present as concomitant co-morbidities, complicating the management of each other and portending a greater mortality. 1 Roger VL Go AS Lloyd-Jones DM Adams RJ Berry JD Brown TM Carnethon MR Dai S de Simone G Ford ES Fox CS Fullerton HJ Gillespie C Greenlund KJ Hailpern SM Heit JA Ho PM Howard VJ Kissela BM Kittner SJ Lackland DT Lichtman JH Lisabeth LD Makuc DM Marcus GM Marelli A Matchar DB McDermott MM Meigs JB Moy CS Mozaffarian D Mussolino ME Nichol G Paynter NP Rosamond WD Sorlie PD Stafford RS Turan TN Turner MB Wong ND Wylie-Rosett J American Heart Association Statistics Committee and Stroke Statistics SubcommitteeHeart disease and stroke statistics–2011 update: a report from the American Heart Association. Circulation. 2011; 123: e18-e209 Crossref PubMed Scopus (4399) Google Scholar Catheter ablation offers improvement in ejection fraction (EF) and cardiovascular outcomes in patients with HFrEF. 2 Sugumar H Prabhu S Costello B Chieng D Azzopardi S Voskoboinik A Parameswaran R Wong GR Anderson R Al-Kaisey AM Ling LH Kotschet E Taylor AJ Kalman JM Kistler PM Catheter ablation versus medication in atrial fibrillation and systolic dysfunction: late outcomes of CAMERA-MRI study. JACC Clin Electrophysiol. 2020; 6: 1721-1731 Crossref PubMed Scopus (19) Google Scholar ,3 Packer DL Mark DB Robb RA Monahan KH Bahnson TD Poole JE Noseworthy PA Rosenberg YD Jeffries N Mitchell LB Flaker GC Pokushalov E Romanov A Bunch TJ Noelker G Ardashev A Revishvili A Wilber DJ Cappato R Kuck KH Hindricks G Davies DW Kowey PR Naccarelli GV Reiffel JA Piccini JP Silverstein AP Al-Khalidi HR Lee KL CABANA InvestigatorsEffect of catheter ablation vs antiarrhythmic drug therapy on mortality, stroke, bleeding, and cardiac arrest among patients with atrial fibrillation: the CABANA randomized clinical trial. JAMA. 2019; 321: 1261-1274 Crossref PubMed Scopus (846) Google Scholar This study aimed to examine the longitudinal change in EF and potential predictors of early and long-term improvement in EF (early improved EF [EiEF] and late improved EF [LiEF], respectively) in patients with HFrEF after AF ablation.