Emerging Trends on the Correlation Between Diabetes and Oxidative Stress from 2003 to 2022: A Bibliometric Analysis

Abstract Background: Diabetes mellitus (DM) and its complications pose serious threats to global public health. As diabetes is a systemic metabolic disease, various studies have shown that it is associated with oxidative stress. Therefore, studies linking diabetes and oxidative stress have received considerable attention. However, no previous studies have analysed the relationship between diabetes and oxidative stress through a bibliometric approach. To fill this knowledge gap and summarise the research hotspots and trends, we conducted a comprehensive bibliometric analysis of global scientific publications in this field. Methods: We extracted all relevant English-language publications on diabetes and oxidative stress from the Web of Science between 1 January 2003 and 31 October 2022. CiteSpace V 5.8.R3, VOSviewer 1.6.16, and two online analysis platforms were used for bibliometric and visual analyses. Results: A total of 44291 articles were identified, including 33,710 articles, 9473 reviews, and 1108 meeting abstracts. The number of publications has increased gradually over the past 20 years. China and the United States are the largest contributors to publications in this field. China Med University is the institution with most publications, and LU CAI is the author with the most publications. There is relatively little collaboration among institutions in different countries. The journal that published the most papers related to diabetes and oxidative stress is the International Journal of Molecular Sciences. According to co-cited references result, ‘bioactive compounds’, ‘SGLT2 inhibitors’, ‘diabetic cardiomyopathy’, and ‘diabetic retinopathy’ are the main research hotspots. Based on the results of the topic evolution, ‘risk’, ‘expression’, ‘oxidative stress’, and ‘antioxidant activity’ are focal points of current research. Conclusion: This study provides a systematic and objective view of the field, which helps readers evaluate the characteristics of publications involving diabetes and oxidative stress and helps researchers formulate rational research protocols.