Treatment-related adverse events of EZH2 inhibitor therapies in clinical trials: a systematic review and meta-analysis

Review question / Objective: In this study, we used conventional Meta-analysis and Network meta-analysis (NMA) to evaluate the survival outcomes of best supportive care only and cytoreductive treatment before transplantation, survival outcomes of different disease states at transplantation, and the effects of each treatment on survival outcomes of MDS, respectively, with a view to comprehensive clinical treatment and individualized treatment of MDS patients before transplantation, providing evidence-based medical evidence, prolonging survival time and improving life quality. Information sources: We will search articles in three electronic database including PubMed, EMBASE and Cochrane Library. All the English publications until 2022 will be searched without any restriction of countries or article type. Reference list of all selected articles will independently screened to identify additional studies left out in the initial search.