132. Carbapenem-resistant Enterobacteriaceae colonization in a Neonatal Intensive Care Unit in Bogotá, Colombia: Characterization and clinical outcomes

Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) infections is a global public health problem, especially among vulnerable populations. Studies exploring these outcomes in neonates colonized with CRE are scarce. The aim is to explore differences in clinical outcomes between CRE-colonized versus CRE-non-colonized neonates. Methods A retrospective, observational, and longitudinal cohort study was performed for surveillance of CRE colonization in the neonates admitted between 2018-2021 to NICU in Bogotá, Colombia. Results From 462 clinical records, 21 (4,5%) were CRE colonized neonates. We found a difference in median gestational age to birth (34 weeks in CRE-colonized vs 37 weeks in non-CRE colonized p 0,018), any previous antibiotic therapy (71% vs 25% p 0,005), carbapenem use before admission (19% vs 1,6% p 0,01), CRE isolation in any sterile fluid during sepsis episodes (14% vs 0% p 0,004), use of empiric carbapenem therapy in sepsis episodes (42% vs 6,3% p 0,0003), empiric therapy for CRE infection (28% vs 6,3% p 0,01), and hospital length of stay (22 vs 11 days p 0,007). We did not find difference in sepsis episodes (66% vs 39% p 0,058) and mortality (4,8% vs 7,9%) among both groups. Conclusion Gestational age, prior use of any antibiotic or carbapenems, CRE isolation in sterile fluid during sepsis episodes, and higher length of stay were more frequently identified among CRE-colonized neonates versus CRE non-colonized neonates. Disclosures All Authors: No reported disclosures.