Rapid identification of in vitro cell toxicity using an electrochemical membrane screening platform

Yvonne Kohl, Nicola William,Elisabeth Elje, Nadine Backes,Mario Rothbauer, Annamaria Srancikova,Elise Rundén-Pran,Naouale El Yamani,Rafi Korenstein,Lea Madi,Alexander Barbul,Katarina Kozics,Monika Sramkova, Karen Steenson,Alena Gabelova,Peter Ertl, Maria Dusinska,Andrew Nelson

Bioelectrochemistry（2023）

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摘要

•Electrochemical study of interaction of three toxicants with lipid monolayer.•Effect of three toxicants on cell viability and genotoxicity.•Benchmarking of model membrane results with live cell assays.•Electrochemical characterisation of membrane interaction mechanism of toxicants.•Identification of biomembrane damage using fluorescent probe assay.

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