Ductal adenoma with AKT1 and EGFR mutations: Report of a case and review of literature

A ductal adenoma is a rare benign epithelial tumour of the breast. Its origin is unclear, but some authors consider that they arise from intraductal papilloma that undergoes sclerosis and lose their papillary architecture. A 43-year-old woman presented a palpable mass in the right breast. Mammography revealed a well-demarcated nodule of 9 mm. Histological examination showed a nodular proliferation of glands without papillary structures circumscribed by a dense fibrous wall. Glandular tubules were round or ovoid. The epithelial cells showed no atypia and mitosis were absent. Gene mutation testing has been performed. To the best of our knowledge, we reported the first case of a ductal adenoma with AKT1 and EGFR mutations. We also reviewed the literature concerning the molecular profile of ductal adenoma and papillary lesions.