A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules

Dear Editor Sarcomas are a group of heterogeneous mesodermic rare tumors with high incidence in children,reaching up to 20％of neoplasms.Standard treatment for sarcomas is surgical resection,and only some patients are treated with chemotherapy and/or radiation therapy.The 5-year relative survival rate for patients with metastatic sarcoma is only 15％.1 Therefore,new treatments are required to increase the survival of these patients.In recent years,microRNAs have shown promising results as prognostic and diagnostic biomarkers in multiple types of sarcoma,2,3 so unique miRNA patterns and miRNA profiles identification could improve diagnosis and new therapies development.3-5 Here,we analyzed changes in miRNA expression in sarcoma.With in-depth bioinfor-matics analysis,the use of association rules,and reported gene-drug associations,we established a new flow chart for treatment analysis,identifying several potential new treatments for sarcoma patients.