Risk Factors of Sepsis Associated Acute Kidney Injury in Patients with Sepsis: A Meta-Analysis

Abstract Introduction Sepsis associated acute kidney injury (SAKI) is a common complication of sepsis with high incidence and mortality around the world. SAKI characterized by low survival rate, poorlong-term prognosis and quality of life of patients, causes huge economic burden to family and society. A large amount of evidence indicates that early diagnosis and necessary treatment of SAKI can effectively improves the prognosis of patients. However, at present, laboratory indicators for early diagnosis of SAKI are limited. Therefore, understanding the risk factors associated with SAKI is crucial for early prediction of SAKI. Method The meta-analysis was conducted with PRISMA statement. All studies are collected from PubMed, Web of Science, Cochrane library, Wiley online library and CNKI databases, and all published from the initiation of the database to Feb 11, 2022, were included. Result A total of 25 studies were included in this meta-analysis, with statistically significant risk factors as follows: diabetes [1.79 (1.43 2.24)], hypotension (MAP < 65 mmHg) [2.25 (1.88 2.70)], coagulation dysfunction [1.14 (1.04 1.24)], liver disease [1.68 (1.28 2.20)], heart disease [1.89 (1.54 3.31)], high APACHEII scores [1.25 (1.02 1.53)], lactic acidosis [1.65 (1.38 1.97)], oliguria [ 1.45 (1.01 2.08), high serum creatinine (> 88 mol/l) [3.84 (2.10 7.04)]. Conclusion Diabetes, hypotension (MAP < 65 mmHg), coagulation dysfunction, liver disease, heart disease, high APACHEII score, lactic acidosis, oliguria, high serum creatinine are the risk factors of SAKI.