Economic impact of bladder cancer (BC) in the United States (US).

479 Background: Incidence and mortality for BC has changed very little over the past 20 years. Approximately 40% of patients with high-risk non-muscle invasive BC eventually recur/progress. It is important to understand the economic impact of disease recurrence/progression in BC. Methods: An economic model was constructed to calculate the number of patients receiving each treatment modality at every stage of disease and their respective costs. Epidemiological data was based on the CancerMPact Patient Metrics (PM) database, and treatment modality data retrieved from CMP Treatment Architecture (TA), 2021 version. Resource utilization and costs were obtained from the medical literature and public data sources. Only direct costs were considered. Results: There were an estimated 83,532 newly diagnosed BC patients of all stages in 2021 with a projected total cost of treatment of $2,584,783,728. Average cost per patient varied from $19,521 (stage 0a) to $169,533 (metastatic disease) (Table). Cost profile differed substantially among the stages of disease. For the 75,760 patients that were expected to have a recurrence in 2021, an additional cost of $3,953,096,316 was estimated at an average cost per patient of $52,179. The expected total cost to treat newly diagnosed and newly recurrent patients is reported in this model, with the total cost in 2021 estimated to exceed $6.5 billion. Conclusions: Treatment and resource costs increase for BC as the disease recurs/progresses. More effective treatments earlier in the disease setting to delay recurrence/progression may reduce the economic burden associated with BC. [Table: see text]