Diversified Cassane Family Diterpenoids from the Leaves of Caesalpinia Minax Exerting Anti-Neuroinflammatory Activity Through Suppressing MAPK and NF-κB Pathways in BV-2 Microglia

The new cassane diterpenoid, caeminaxin A, alleviated the expression of iNOS and COX-2 protein and down-regulated of intracellular MAPK and NF-κB signaling pathways. The results implied that cassane diterpenoids had potential to be developed into therapeutic agents for neurodegenerative disorders such as Alzheimer's disease.