Heterogeneity Of Mri-Detected Cartilage Damage In Kellgren-Lawrence 2 & 3 Knees And Implications For Clinical Trials: The Osteoarthritis Initiative (OAI)
Osteoarthritis and Cartilage(2023)
Abstract
Purpose: Many potential disease-modifying osteoarthritis drugs (DMOADs) have been investigated, but to date no DMOADs that slow or stop disease progression have been approved by the Food and Drug Administration (FDA) or the European Medicines Agency (EMA). A potential reason for the lack of demonstrated efficacy may be reliance on radiographs for defining structural inclusion and exclusion criteria for clinical trials, such as use of joint space width and Kellgren-Lawrence (KL) grade as surrogates for cartilage damage. Our aim is to report the distribution of cartilage damage seen on knee MRI in a sample of knees with radiographic KL 2 and 3 OA that would potentially qualify for a DMOAD trial.
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Key words
cartilage damage,osteoarthritis initiative,knees,mri-detected,kellgren-lawrence
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