#6871 risk factors for short-term chronic kidney disease after acute kidney injury with recovery of normal renal function

Abstract Background and Aims Acute kidney injury (AKI) is a clinico-biological syndrome encompassing the entire spectrum of acute renal failure that is responsible for a higher short-term risk of developing chronic kidney disease (CKD) even after recovery of normal renal function. The risk of developing new CKD has been estimated at 4 times that of the population without an episode of AKI in several studies. Our objective was to identify its risk factors Method We conducted a retrospective descriptive study that included patients hospitalized for AKI with recovery of normal renal function between January 2002 and December 2015 who were followed up to one year after discharge. In order to achieve our objective, we collected data related to the patients' age, history, multitargeted or not, mechanism of AKI, KDIGO stage, glomerular filtration rate (GFR) at hospital discharge, using a pre-designed form. Results In the short term, 176 patients were followed up, among whom 18 patients (10.2%) had developed CKD with a mean delay of 9.07±0.4 months. Patients reaching CKD stage were older, half were over 70 years old, 61% were diabetics; 13 of them were multitargeted and 15 had a GFR < 60 ml/min at discharge. All these parameters were statistically different from patients who did not progress to CKD. However, regardless of the mechanism of AKI or the KDIGO stage selected, these two parameters were not retained as risk factors for the development of CKD. In multivariate analysis by logistic regression, only being an elderly subject remains a significant risk factor (p = 0.034) of developing short-term CKD with an OR of 3.3; 95% CI (1.09 - 10.01) Conclusion Our results suggest that the development of CKD occurred most often in the first year following an episode of AKI, hence the interest in following these patients.