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microRNA-124与疾病的研究进展

ZHANG Zhifeng, YUAN Ruiyang,DING Haimai,ZHANG Xueming

Journal of Medical Molecular Biology（2023）

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Abstract
microRNA(miRNA)是一类长度为20～24个核苷酸的非编码单链RNA,被称为转录后调控因子.miRNA是在转录后调控其靶基因发挥作用.miRNA表达的改变在多种疾病的发生发展过程中发挥重要的调控作用.其中,microRNA124(miR-124)是目前的研究热点之一,它在多种肿瘤中低表达,并在细胞增殖、侵袭转移及凋亡等方面发挥重要的抑癌作用,密切参与恶性肿瘤的发生、发展和预后.文章综述了非恶性疾病与恶性疾病中miR-124的作用机制,为疾病的诊断与治疗提供理论证据.
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