Whole-genome sequencing rule-out of suspected hospital-onset Rhizopus outbreaks

Victoria T. Chu,Saba Nafees,Eric Waltari,Nicole McNeil,Carolyn Caughell,Estella Sanchez-Guerrero,Lusha Wang,Kim Stanley, Gail Cunningham,Joan Wong,Maíra Phelps,Cristina M. Tato,Steve Miller, Joseph L. DeRisi,Deborah S. Yokoe,Lynn Ramirez-Avila,Charles R. Langelier

Infection Control & Hospital Epidemiology（2023）

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摘要

Abstract Two independent temporal-spatial clusters of hospital-onset Rhizopus infections were evaluated using whole-genome sequencing (WGS). Phylogenetic analysis confirmed that isolates within each cluster were unrelated despite epidemiological suspicion of outbreaks. The ITS1 region alone was insufficient for accurate analysis. WGS has utility for rapid rule-out of suspected nosocomial Rhizopus outbreaks.

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关键词

outbreaks,sequencing,whole-genome,rule-out,hospital-onset

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