Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma.

Ang Li,Bai Ji,Yongsheng Yang,Bicheng Ye, Qinmei Zhu,Xintong Hu,Yong Liu,Peiwen Zhou, Juanjuan Liu,Ranran Gao,Qi Zhou,Boxi Kang,Yanfang Jiang

Frontiers in Immunology（2023）

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摘要

Collectively, our study revealed the functional state, clinical significance, and intercellular communication of immunosuppressive cells in HCC at single-cell resolution. Moreover, PVR/PVRL2, interact with TIGIT act as prominent coinhibitory signals and might represent a promising, efficacious immunotherapy strategy in HCC.

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single-cell RNA sequencing,HCC,TME,immunotherapy,PVR/PVRL2

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