Inhibition of ANXA2 activity attenuates epileptic susceptibility and GluA1 phosphorylation

Limin Ma,Qingyuan Wu,Jinxian Yuan,You Wang,Peng Zhang,Qiankun Liu,Dandan Tan,Minxue Liang,Yangmei Chen

CNS Neuroscience & Therapeutics（2023）

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摘要

This study covers a previously unknown and key function of ANXA2 in epilepsy. These findings indicate that ANXA2 can regulate excitatory synaptic activity mediated by AMPAR subunit GluA1 to improve seizure activity, which can provide novel insights for the treatment and prevention of epilepsy.

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关键词

AMPAR, ANXA2, epilepsy, excitatory synaptic transmission, GluA1, seizure

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