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Extracellular Vesicles Derived circSH3PXD2A Inhibits Chemoresistance of Small Cell Lung Cancer by miR-375-3p/YAP1.

Fengmei Chao, Yang Zhang,Lei Lv, Yaqin Wei,Xiaoyan Dou,Na Chang,Qiyi Yi,Ming Li

International Journal of Nanomedicine（2023）

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Abstract
Our results manifest that EVs-derived circSH3PXD2A inhibits the chemoresistance of SCLC through miR-375-3p/YAP1 axis. Moreover, EVs-derived circSH3PXD2A may serve as a predictive biomarker for DDP-resistant SCLC patients.
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Key words
circsh3pxd2a,extracellular vesicles,mir-375-3p,yap1,chemoresistance,small cell lung cancer
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