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Increased prevalence of nodular thyroid disease in patients with Klinefelter syndrome.

Rosa di Fraia,Daniela Esposito,Lucia Digitale Selvaggio,Francesca Allosso,Roberto Alfano,Mario Rotondi,Giancarlo Balercia,Giacomo Accardo,Daniela Pasquali

Endocrine（2023）

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Abstract
We observed a significantly higher prevalence of nodular thyroid disease in KS compared to the control group. The increase in nodular thyroid disease is likely linked to low levels of FT4, inappropriate TSH secretion, and/or genetic instability.
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Key words
Thyroid, Thyroid nodules, Klinefelter syndrome, Hashimoto's thyroiditis, 47, XXY
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