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Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo-glycans

Lucrezia Morticelli,Charlotte Rossdam,Samanta Cajic,Dietmar Boethig,Mikhail Magdei,Sugat R. Tuladhar,Bjoern Petersen,Konrad Fischer,Erdmann Rapp,Sotirios Korossis,Axel Haverich,Angelika Schnieke,Heiner Niemann,Falk Buettner,Andres Hilfiker

XENOTRANSPLANTATION（2023）

Cited 3|Views18
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Abstract
Genetic deletion of GGTA1 or GGTA1/CMAH removes specific epitopes providing a more human-like glycosylation pattern, but at the same time changes distribution and levels of other porcine glycans that are potentially immunogenic.
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Key words
CGE-LIF,decellularization,glycosphingolipid,N-glycan,pericardium,xenoantigen
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