Subfoveal Choroidal and Macular Thickness Assessed with Optical Coherence Tomography in Indonesian Subjects with Type 2 Diabetes: A Cross-Sectional Study

Objective: The present study aims to assess the dif-ference in choroidal and macular thickness in type 2 diabetes (T2D) patients with and without diabetic retinopathy (DR).Materials and methods: This cross-sectional analytic study included 84 eyes from 56 subjects by consecutive sampling which were divided into control, T2D without DR/non-diabetic retinopathy (NDR), and T2D with DR/ /diabetic retinopathy (DR) group. The subjects were patients with T2D aged 40-60 years with or without DR, with normal intraocular pressure, and never received any DR therapy. The data collected were age, gender, mean arterial pressure, glycemic control, choroidal thickness (CT), and macular thickness (MT).Results: Mean age of the NDR group was 51.67 +/- +/- 4.64 years, the DR group was 52.45 +/- 4.46 years, and the control group was 51.31 +/- 5.72 years. Subjects in DR group (247.57 +/- 57.95 microns) had significantly thinner choroids when compared to the NDR group (266.68 +/- 51.76 microns), they both also had significantly thinner choroids when compared to the control group (283.07 +/- 69.98; p = 0.042). On the contrary, subjects in DR group (263.79 +/- 45.17 microns) had thicker macula compared to the NDR (236.11 +/- 26.49 microns) and control group (239.82 +/- 17.42 microns; p = 0.015). Conclusions: Subjects with type 2 diabetes and retin-opathy had significantly thinner choroid and thicker macula when compared to non-diabetic retinopathy group. The thinning of choroid and thickening of macula develops as the disease progresses to diabetic retinopathy. (Clin Diabetol 2023; 12; 2: 80-86)