Synthesis, characterization, crystal structure, thermal and redox behaviour and antiproliferative studies of morpholine-based two copper(II) compounds

Two novel copper(II) complexes, [Cu(L)(Cl)(2)](H2O) (1) and [Cu(L)(N-3)(2)] (2), have been synthesized from a morpholine-based N,N,N donor tridentate Schiff base ligand, (E)-N-(2-morpholinoethyl)-1-phenyl-1-(pyridin-2-yl)methanimine (L). Ligand (L) and its stabilized complexes, 1 and 2, have been comprehensively characterized by different physical and spectroscopic techniques. Solid-state single-crystal X-ray structures of both 1 and 2 have been determined. Powder X-ray diffraction studies on the bulk samples of 1 and 2 have been executed to demonstrate that the synthesized bulk materials retain their solid-phase purity as that exists in the single crystals. Cyclic voltammetric experiments have been done to demonstrate the redox behaviour of 1 and 2. UV-vis spectra of the copper(II) complexes with variation in time were accrued to probe that both 1 and 2 retain their stability in solution. Thermogravimetric analysis (TGA) has been performed to collate the thermal stability of 1 along with its possible thermal degradation behaviour. Room temperature magnetic moments of 1 and 2 have been determined. Cytotoxic activity of 1 and 2 has been screened against non-small human lung cancer cell, A549.