Comparative cytotoxicity of Lu-177 on various lung cancer cells and in vivo targeting of Lu-177-labeled cetuximab
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY(2023)
Abstract
Differences in cellular radiosensitivity and the binding affinity of radiopharmaceuticals could directly affect the radiotherapeutic effects. In this study, we investigated the radionuclide (Lu-177) induced radiosensitivity of serval non-small-cell lung cancer cells (NSCLCs) as well as the binding affinity of cetuximab to those cells. The apoptosis of NSCLCs caused by Lu-177 was related to the DNA double-strand damage and was cell-type dependent. We also proved that the introduction of Lu-177 to the antibody could enhance its cytotoxic effect on NSCLCs. The [Lu-177]Lu-DOTA-cetuximab could accumulate in the HCC827 tumor xenografts with excellent stability according to in vivo SPECT/CT imaging and the biodistribution results. The [Lu-177]Lu-DOTA-cetuximab showed high potential to be used for targeting diagnosis and radiotherapy in lung cancers.
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Key words
Lung cancer, Radiosensitivity, Lutetium-177, Anti-EGFR antibody, Tumor targeting
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