Vibrational Circular Dichroism Studies on Axially Chiral Carbodiimides and Allenes

The axial chirality of molecules with two consecutive dou-ble bonds (X=Y=Z) has not been well studied because of a lack of analyt-ical methods and because of difficulties in their preparation in enantio-merically pure forms. This Synpacts article describes the use of vibrational circular dichroism spectroscopy to study the stereochemis-try of carbodiimides and allenes. A strategy to obtain carbodiimides with one-handed chirality by using conformationally restrained frame-works is also discussed.1 Introduction2 Carbodiimides with Partially Biased Axial Chirality and One-Hand-ed Axial Chirality3 Axially Chiral Allenes4 Conclusions