Oxetane Ring‐Opening Reaction: A Key Step for the Preparation of Substituted (Fluoro)alkenyl as Acyclonucleoside Mimics

David Leparfait, Feng Xiao,Delphine Coupri, Sabrina Gueulle,Florie Desriac,Aurélie Budin‐Verneuil,Nicolas Verneuil,Axel Hartke,Emmanuel Pfund,Thierry Lequeux

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY（2023）

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摘要

Tri- and tetra-substituted alkenes, including fluoroalkenes, were prepared by a selective ring-opening reaction of functionalized oxetanes. The introduction of adenine nucleic base allows the synthesis of alkenyl and fluoroalkenyl derivatives that were evaluated towards DltA enzyme as potential nucleoside mimics.

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alkenes,cycloaddition,fluorine,nucleosides,nucleophilic substitution

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