Genetic and immunological markers of the formation of metabolic syndrome in schoolchildren (on the example of the Perm Region)

The justification of genetic and immunological markers of the formation of metabolic syndrome in schoolchildren attending secondary school (on the example of the Perm Region) was carried out. It was found that the group of children with metabolic syndrome and excess body weight in relation to the comparison group was characterized by an increase in CD19+ expression, a decrease in the content of anti-inflammatory cytokine IL4, overexpression of pro-inflammatory cytokines, an imbalance of lipid-carbohydrate metabolism, statistically significant changes in the frequency of genotypes associated with metabolic syndrome. Candidate immunological (CD19+, IL1b, IL4) and genetic (ADRB2 rs1042713, PPARA rs4253778) markers are recommended to be used as indicators for identifying early signs of metabolic syndrome in school-age children living in the Perm region.